Vascular Growth Factors and Angiogenesis

Role of angiogenesis and angiogenic factors in acute and chronic wound healing
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Exp Cell Res ; : Epidermal growth factor receptor-mediated autocrine and paracrine stimulation of human transitional cell carcinoma. Cancer Res ; 53 : Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun ; : Vascular endothelial growth factor is a secreted angiogenic mitogen.

Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med ; 5 : Vascular endothelial growth factor VEGF and its receptors. EMBO J ; 18 : J Biol Chem ; : Evidence from Cys to Ser mutations. Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family.

Reversible acetylation regulates Vascular Endothelial Growth Factor Receptor-2 activity.

A structural superfamily of growth factors containing a cystine knot motif. Cell ; 73 : Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev ; 18 : 4 Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma. Hum Pathol ; 29 : Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

The Angiogenic Growth Factors HGF and VEGF in Serum and Plasma from Neuroblastoma Patients

J Clin Invest ; 84 : Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature ; : Vascular endothelial growth factor rhVEGF stimulates direct angiogenesis in the rabbit cornea. In Vivo ; 8 : Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch Ophthalmol ; : Vascular endothelial growth factor C induces angiogenesis in vivo. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity.

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene ; 9 : J Cancer Res Clin Oncol ; : Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab Invest ; 71 : Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol ; 16 : Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells.

Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Circ Res ; 77 : Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. Invest Ophthalmol Vis Sci ; 37 : Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart.

Am J Physiol ; : H -H Hypoxia-induced expression of VEGF is reversible in myocardial vascular smooth muscle cells. Ware JA, Simons M. Angiogenesis in ischemic heart disease. Nat Med ; 3 : Benjamin LE, Keshet E. Conditional switching of vascular endothelial growth factor VEGF expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal.

Vascular endothelial growth factor and angiogenesis.

Mustonen T, Alitalo K. Endothelial receptor tyrosine kinases involved in angiogenesis. J Cell Biol ; : Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development ; : Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis. Endocrinology ; : Hubbard SR.

Structural analysis of receptor tyrosine kinases. Prog Biophys Mol Biol ; 71 : Tyrosine kinases in disease: overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials.

Expert Opinion on Investigational Drugs ; 7 : High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell ; 72 : Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flkdependent.

Expression of vascular endothelial growth factor VEGF family members in breast cancer. Jpn J Cancer Res ; 90 : Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res ; 59 : Hepatology ; 30 : Droller MJ. Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer.

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J Urol ; : Concentrations of vascular endothelial growth factor in the sera of gastric cancer patients. Oncol Rep ; 5 : Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor. Clin Cancer Res ; 5 : Nucleic Acids Res ; 27 : Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo.

Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy.

1. Introduction

Cancer Res ; 56 : Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth. Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. Cell Growth Differ ; 9 : 49 Antivascular endothelial growth factor receptor fetal liver kinase 1 monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.

Cancer Res ; 59 : 99 Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. The design and synthesis of a novel, orally active VEGF receptor tyrosine kinase inhibitor. Proc Am Assoc Cancer Res ; 40 : 69a.

Proc Am Assoc Cancer Res ; 40 : a. Modulation of in vivo growth of thyroid tumor-derived cell lines by sense and antisense vascular endothelial growth factor gene. Oncogene ; 18 : Role of protein kinase C isoforms in phorbol ester-induced vascular endothelial growth factor expression in human glioblastoma cells. Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts.

Cancer Res ; 58 : Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest ; 95 : Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor.


Jpn J Cancer Res ; 90 : 93 The effect of antibody against vascular endothelial growth factor on tumor growth and metastasis. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res ; 57 : Proc Am Soc Clin Oncol ; 17 : a. A phase II trial of humanized monoclonal anti-vascular endothelial growth factor antibody rhumAb in hormone refractory prostate cancer.

Proc Am Soc Clin Oncol ; 18 : a. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate. J Med Chem ; 42 : Small molecule inhibitors of tumor-promoted angiogenesis, including protein tyrosine kinase inhibitors.

Bibliographic Information

Epub Sep The cell-responsive hydrogel led to angiogenesis specifically within the hydrogel, while soluble VEGF release led to increased vascular density in the surrounding tissue [ 20 ]. J Cell Mol Med. The unique vascular endothelial cell selectivity and hypoxic induction of VEGF have contributed to the growing recognition of its physiologic importance as an angiogenic agent. This review discusses the mechanisms that underlie tumor angiogenesis, provides a few examples of angiogenic pathways that are commonly seen in most tumor types, and discusses the challenges of antiangiogenic cancer therapy.

Pharmacol Ther ; 82 : Phase 1 dose-escalating trial of SU, a novel angiogenesis inhibitor in patients with advanced malignancies. J Clin Oncol ; 18 : a. First preclinical and clinical results with the antiangiogenetic substance SU in malignancies. Eur J Cancer ; 35 suppl 5 : S62a. SU is a potent, broad spectrum angiogenesis inhibitor that exhibits anti-tumor properties.

Proc Am Assoc Cancer Res ; 40 : 68a. Inhibitors of protein kinases: CGP , a protein kinase inhibitor with potential as an anticancer agent. This Article doi: Services E-mail this article to a colleague Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager.

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Related Content Load related web page information. Current Issue September , 24 9. Your browser does not have JavaScript enabled and some parts of this website will not work without it. For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome. Our Cookie Policy explains how you can opt-out of the cookies we use. VEGF can induce growth of pre-existing angiogenesis or de novo vessels vasculogenesis , and is therefore key for embryonic development and vessel repair. VEGF is also hijacked by solid tumors to support their neoplastic growth.

The activation of VEGF receptors is considered one of the most critical events in angiogenesis 3. VEGF has activity in diverse cell types, such as muscle 4 and neuronal cells 5 , however its main actions are on endothelial cells 6.

Family members play key roles in orchestrating the formation of new blood vessels, such as induction of gene expression, regulation of vascular permeability, and promotion of cell migration, proliferation and survival. As a consequence, disruption of VEGF pathways in mice increases embryonic lethality due to circulatory problems 8.

Expression of VEGF decreases significantly after birth. However, localized levels can be up-regulated in tissues undergoing wound healing or fracture repair 2.

Therapeutic Angiogenesis for Treating Cardiovascular Diseases

Recent studies have emphasized the role VEGF plays in pathological conditions involving the formation of new blood vessels, such as cancer, rheumatoid arthritis and age-related macular degeneration 3 ,9, Once the angiogenic switch is induced to promote the formation of new blood vessels, a complex and highly regulated sequence of events takes place. By activating multiple proteases, this pathway promotes the degradation of the basement membrane surrounding the existing vessel. This is followed by increased proliferation of endothelial cells, the formation of a lumen and a new basement membrane, and the fusion of newly formed vessels 2.

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